Valproic acid (VPA) is an effective drug, which is preferred for the treatments of epilepsy and various kinds of seizures. Nonetheless, VPA has many life‐threatening side effects associated with free radical production. Alpha‐lipoic acid (ALA) is a powerful antioxidant, which can scavenge reactive oxygen species (ROS). The effects of ALA against VPA‐stimulated brain injury were investigated. In this study, Sprague‐Dawley rats were divided as four groups: Group I, control rats; Group II, ALA‐administered rats (50 mg/kg/d); Group III, VPA‐administered rats (0.5 g/kg/d); Group IV: VPA‐ and ALA‐administered rats at the same dose and time. According to the results, VPA increased lipid peroxidation, protein carbonyl, advanced oxidation protein products, total oxidant status, nitric oxide levels and glutathione‐S‐transferase, adenosine deaminase, xanthine oxidase activities, decreased glutathione, total antioxidant capacity levels, catalase, superoxide dismutase, glutathione peroxidase, sodium‐potassium ATPase, and paraoxonase activities. Treatment with ALA reversed these effects. In conclusion, we may suggest that ALA may be a good candidate for prevention of VPA‐induced brain injury.

中文翻译：

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硫辛酸可预防丙戊酸大鼠的脑损伤。

丙戊酸（VPA）是一种有效的药物，在治疗癫痫和各种癫痫发作中较为理想。但是，VPA具有许多与自由基产生相关的威胁生命的副作用。硫辛酸（ALA）是一种强大的抗氧化剂，可以清除活性氧（ROS）。研究了ALA对VPA刺激的脑损伤的影响。在这项研究中，将Sprague-Dawley大鼠分为四组：第一组，对照组。第II组，ALA给药的大鼠（50 mg / kg / d）；第三组，VPA给药的大鼠（0.5 g / kg / d）; 第四组：VPA和ALA给药的大鼠，剂量和时间相同。根据结果​​，VPA可增加脂质过氧化，羰基蛋白，高级氧化蛋白产物，总氧化剂状态，一氧化氮水平和谷胱甘肽-S-转移酶，腺苷脱氨酶，黄嘌呤氧化酶活性，谷胱甘肽降低，总抗氧化能力水平，过氧化氢酶，超氧化物歧化酶，谷胱甘肽过氧化物酶，钠钾ATP酶和对氧磷酶活性。用ALA治疗逆转了这些作用。总之，我们可能建议ALA可能是预防VPA诱发的脑损伤的良好候选者。