One of the well‐known toxicants of the mammary tissue is 7,12‐dimethylbenz[a]anthracene (DMBA). This study was carried out to investigate the possible prophylactic's role of increased dietary intake of vitamin K on the induction of toxicity in the lung tissue. Twenty‐eight Wistar albino rats (120‐150 g) were randomly divided into different groups. Group 1 served as the control and were fed with a normal diet (containing the recommended daily allowance of vitamin K (0.0075%)). Groups 2 and 3 received a single dose of DMBA (80 mg/kg body weight) intragastically. In addition, group 3 rats were maintained on surplus vitamin K diet (0.075% diet) as against the group 2 animals that were on a normal diet. Group 4 rats were on surplus vitamin K diet (0.075% diet) throughout the experimental period of 16 weeks. Our results revealed that supplementation of diet with surplus vitamin K significantly increased the activities of catalase. Superoxide dismutase, glutathione‐S‐transferase, and glutathione peroxidase were significantly increased in the serum and lungs when compared with the DMBA‐treated group, which was maintained on a normal diet. Significant alterations in malondialdehyde, nitric oxide, granulocyte‐macrophage colony‐stimulating factor, and interleukin 17F were observed in rats challenged with DMBA‐fed normal diets but were normalized in rats with surplus vitamin K. These alterations and reversal were confirmed by histopathology studies. This suggests the prophylactic benefit of increased dietary intake of vitamin K without any observed deleterious effect on DMBA‐induced pulmonary toxicity.

中文翻译：

---

维生素K饮食补充对7,12-二甲基苯并[a]蒽诱发的肺功能障碍的影响。

乳腺组织的一种著名的有毒物质是7,12-二甲基苯并[a]蒽（DMBA）。进行这项研究以调查饮食中维生素K摄入量增加对肺组织毒性的诱导作用的预防作用。将28只Wistar白化病大鼠（120-150 g）随机分为不同的组。第一组作为对照组并接受正常饮食（包含建议的每日维生素K摄入量（0.0075％））。第2组和第3组在胃内接受单剂量的DMBA（80 mg / kg体重）。另外，与正常饮食的第2组动物相比，第3组的大鼠维持了过量的维生素K饮食（0.075％的饮食）。在第16周的整个实验过程中，第4组大鼠的维生素K饮食过量（饮食为0.075％）。我们的结果表明，饮食中补充有过量的维生素K会显着增加过氧化氢酶的活性。与维持正常饮食的DMBA治疗组相比，血清和肺中的超氧化物歧化酶，谷胱甘肽S-转移酶和谷胱甘肽过氧化物酶显着增加。在接受DMBA喂养的正常饮食的大鼠中，丙二醛，一氧化氮，粒细胞巨噬细胞集落刺激因子和白介素17F发生了显着变化，但在维生素K过剩的大鼠中恢复了正常。这些变化和逆转得到了组织病理学研究的证实。这表明增加饮食中维生素K摄入量的预防益处，而未观察到对DMBA诱发的肺毒性有有害影响。