ISKpn40-Mediated Mobilization of the Colistin Resistance Gene mcr-3.11 in Escherichia coli.,Antimicrobial Agents and Chemotherapy

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ISKpn40-Mediated Mobilization of the Colistin Resistance Gene mcr-3.11 in Escherichia coli.
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2020-09-21 , DOI: 10.1128/aac.00851-20
Yu-Zhang He _{1,

2,

3} , Teng-Fei Long _{1,

2,

3} , Cai-Ping Chen _{1,

2,

3} , Bing He _{1,

2,

3} , Xing-Ping Li _{1,

2,

3} , Jessica Schuyler _{4,

5} , Liang Chen _{4,

6} , Xiao-Ping Liao _{1,

2,

3} , Ya-Hong Liu _{1,

2,

3,

5} , Jian Sun _{2,

3,

7}

Affiliation

The mobile colistin resistance gene mcr-3 has globally disseminated since it was first reported in 2017 in Escherichia coli. In vitro mobilization assays in this study demonstrate the functionality of the composite transposon structure ISKpn40-mcr-3.11-dgkA-ISKpn40 in wild-type and recA⁻ E. coli strains. These transpositions generated 4-bp duplications at the target sites. This is the first report demonstrating the mobility of the mcr-3.11 gene by transposition.

中文翻译：

ISKpn40 介导的大肠杆菌中粘菌素抗性基因 mcr-3.11 的动员。

自 2017 年在大肠杆菌中首次报道以来，可移动粘菌素抗性基因mcr-3已在全球传播。本研究中的体外动员试验证明了复合转座子结构 IS Kpn40-mcr-3.11-dgkA -IS Kpn40在野生型和recA ^-大肠杆菌菌株中的功能。这些转座在目标位点产生 4 bp 重复。这是第一份通过转座证明mcr-3.11基因移动性的报告。

更新日期：2020-09-21

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