Cytogenetic biodosimetry is a well-known method for quantifying the absorbed dose based on measuring biological radiation effects. To correlate the induced chromosomal abberrations with the absorbed dose of the individuals, a reliable dose-response calibration curve should be established. This study aimed to use frequencies and distributions of radiation-induced dicentric chromosome aberrations to develop a standard dose-response calibration curve. Peripheral blood samples taken from six male donors irradiated by an X-ray generator up to 4 Gy were studied. Three different blood samples were irradiated by known doses, then scored blindly for verification of the proposed calibration curve. Dose estimation was also carried out for three real overexposed cases. The results showed good accordance with the other published curves. The constructed dose-response curve provides a reliable tool for biological dosimetry in accidental or occupational radiation exposures.

中文翻译：

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使用双中心染色体畸变构建和验证体外剂量响应校准曲线。

细胞遗传学生物剂量学是一种众所周知的基于测量生物辐射效应来量化吸收剂量的方法。为了将诱发的染色体畸变与个体的吸收剂量相关联，应建立可靠的剂量反应校准曲线。本研究旨在使用辐射引起的双着丝粒染色体畸变的频率和分布来制定标准的剂量反应校准曲线。研究了从使用高达 4 Gy 的 X 射线发生器照射的六名男性捐献者的外周血样本。三种不同的血液样本以已知剂量照射，然后盲目评分以验证建议的校准曲线。还对三个真实的过度曝光案例进行了剂量估计。结果显示出与其他公布的曲线良好的一致性。