The major histocompatibility class I (MHC-I) complex functions in innate and adaptive immunity, mediating surveillance of the subcellular environment. In humans, MHC-I heavy chains are encoded by three genes: the human leukocyte antigen (HLA)-A, HLA-B, and HLA-C. These genes are highly polymorphic, which results in the expression, typically, of six different HLA class I (HLA-I) proteins on the cell surface, and the presentation of diverse peptide antigens to CD8+ T cells for broad surveillance against many pathogenic conditions. Recent studies of HLA-B allotypes show that the polymorphisms, not surprisingly, also significantly impact protein folding and assembly pathways. The use of non-canonical assembly routes and the generation of non-canonical HLA-B conformers has consequences for immune receptor interactions and disease therapies.

中文翻译：

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HLA-B 多态性：对装配和免疫的影响。

主要组织相容性 I 类 (MHC-I) 复合体在先天性和适应性免疫中发挥作用，介导亚细胞环境的监视。在人类中，MHC-I 重链由三个基因编码：人类白细胞抗原 (HLA)-A、HLA-B 和 HLA-C。这些基因具有高度多态性，通常会导致细胞表面表达六种不同的 HLA I 类 (HLA-I) 蛋白，并向 CD8+ T 细胞呈递不同的肽抗原，以广泛监测多种致病性疾病。最近对 HLA-B 同种异型的研究表明，毫不奇怪，多态性也会显着影响蛋白质折叠和组装途径。非规范组装路线的使用和非规范 HLA-B 构象异构体的生成对免疫受体相互作用和疾病治疗产生影响。