Aim: The aim of this study was to investigate the efficacy of thiol disulfide homeostasis and Ischemia Modified Albumin (IMA) values in predicting the technical difficulties that might be encountered during laparoscopic cholecystectomy.

Materials and Methods: The study included 65 patients who underwent laparoscopic cholecystectomy due to cholelithiasis at the General Surgery Clinic of Ankara Numune Training and Research Hospital. All patients’ demographic data, previous history of cholecystitis, a history of chronic illness, preoperative white blood count (WBC), liver function tests (AST, ALT), amylase and lipase levels, intra-operative adhesion score, the ultrasonographic appearance of gall bladder, duration of hospital stay, duration of operation, thiol disulfide and IMA values were evaluated.

Results: Native thiol and total thiol averages were higher in patients without a history of cholecystitis, and on the other hand, disulfide, disulfide/native thiol rate, disulfide/total thiol rate, native thiol/total thiol rate and IMA averages were higher in patients with a history of cholecystitis. While there was a statistically significant negative correlation between native and total thiol values and age, duration of surgery and duration of hospital stay; IMA, disulfide, disulfide/Total thiol, Native/Total thiol and disulfide/Native thiol rates were higher in older patients with a longer duration of surgery and hospital stay. In addition, preoperative IMA, disulfide, disulfide/Total thiol, Native/Total thiol and disulfide/Native thiol were observed to increase as the degree of intraoperative pericholecystic adhesion increased.

Conclusion: We believe that the evaluation of thiol disulfide homeostasis and IMA parameters prior to laparoscopic cholecystectomy can be used as an effective method for predicting intraoperative difficulties.

目的：本研究的目的是调查硫醇二硫化物稳态和缺血修饰白蛋白 (IMA) 值在预测腹腔镜胆囊切除术中可能遇到的技术困难方面的功效。

材料和方法：该研究包括 65 名因胆石症在 Ankara Numune 培训和研究医院普通外科诊所接受腹腔镜胆囊切除术的患者。所有患者的人口统计学资料、胆囊炎既往史、慢性病史、术前白细胞计数（WBC）、肝功能检查（AST、ALT）、淀粉酶和脂肪酶水平、术中粘连评分、胆囊超声表现评估膀胱、住院时间、手术时间、硫醇二硫化物和 IMA 值。

结果：无胆囊炎病史的患者的天然硫醇和总硫醇平均值较高，另一方面，二硫化物、二硫化物/天然硫醇率、二硫化物/总硫醇率、天然硫醇/总硫醇率和 IMA 平均值较高。有胆囊炎病史的患者。虽然天然硫醇值和总硫醇值与年龄、手术时间和住院时间之间存在统计学上显着的负相关；IMA、二硫化物、二硫化物/总硫醇、天然/总硫醇和二硫化物/天然硫醇的比率在手术时间和住院时间较长的老年患者中较高。此外，观察到术前 IMA、二硫化物、二硫化物/总硫醇、天然/总硫醇和二硫化物/天然硫醇随着术中胆囊周围粘连程度的增加而增加。

结论：我们认为在腹腔镜胆囊切除术前评估硫醇二硫化物稳态和 IMA 参数可作为预测术中困难的有效方法。