Despite tremendous progress in the design and manufacturing of metallic implants, they do not outlive the patient. To illustrate, more than half of hip replacements will fail, mainly due to implant infection and loosening. Surface engineering approaches and, in particular, coatings can facilitate implant bio-functionality via the recruitment of more host cells for new bone formation and inhibition of bacterial colonization. Here, we used electrophoretic deposition to apply a silk fibroin solution consisting of tricalcium phosphate (TCP) and vancomycin as a coating on the surface of additively-manufactured porous titanium. Furthermore, the surface properties of the coatings developed and the release kinetics of the vancomycin were studied to evaluate the applied coating. The in vitro antibacterial behavior of the multifunctional coating, as well as the cell viability and osteogenic differentiation of the MC3T3-E1 cell line were extensively studied. The biomaterials develop...

中文翻译：

---

增材制造的多孔钛上的多功能丝涂层，可防止植入物相关感染并刺激骨再生。

尽管金属植入物的设计和制造取得了巨大进步，但它们的寿命并没有超过患者。举例来说，超过一半的髋关节置换术会失败，主要是由于植入物感染和松动。表面工程方法，特别是涂层可以通过募集更多宿主细胞来形成新骨和抑制细菌定植，从而促进植入物的生物功能。在这里，我们使用电泳沉积将由磷酸三钙 (TCP) 和万古霉素组成的丝素蛋白溶液用作增材制造多孔钛表面的涂层。此外，研究了开发的涂层的表面性质和万古霉素的释放动力学，以评估所应用的涂层。多功能涂层的体外抗菌行为，以及对 MC3T3-E1 细胞系的细胞活力和成骨分化进行了广泛研究。生物材料的发展...