The widespread occurrence of sulfonamides (SAs) in the environment water has rasied great concerns about their potential to antibiotics resistance. In this study, the fluorescence behaviors of sulfamethoxazole (SMZ) representing certain properties of the SAs mixed with three different kinds of cyclodextrins (CDs) in water solutions were investigated, respectively. The result reported that the shapes of the fluorescence peak and its position for the SMZ that were mixed with the CDs were almost the same as those of the standard SMZ, respectively. In addition, compared with the identical control sample the fluorescence of SMZ mixed with each of the CD was greatly enhanced. Therefore, a new simple, and sensitive spectrofluorimetric method for the determination of SMZ was established in water solutions. and the dynamic linear ranges varied from 0.01 to 0.7 mg/L with the detection limit of 7.1 ng/L. And the correlation coefficient was more than 99.9%. Significantly, this new method was successfully applied to direct determination of SMZ in pharmaceutical compounds. Moreover, the results showed that the SMZ could separately form the 1:1 supramolecular compound with each of the CD.

中文翻译：

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基于环糊精在水溶液中的荧光行为测定痕量磺胺甲恶唑的新增强方法。

磺胺类药物 (SAs) 在环境水中的广泛存在引起了人们对其潜在抗生素耐药性的极大关注。在这项研究中，分别研究了代表 SAs 某些性质的磺胺甲恶唑 (SMZ) 与三种不同类型的环糊精 (CDs) 混合在水溶液中的荧光行为。结果表明，与 CD 混合的 SMZ 的荧光峰形状及其位置分别与标准 SMZ 几乎相同。此外，与相同的对照样品相比，与每个CD混合的SMZ的荧光大大增强。因此，建立了一种新的测定水溶液中SMZ的简单、灵敏的荧光分光光度法。动态线性范围从 0 变化。01 至 0.7 mg/L，检测限为 7.1 ng/L。且相关系数大于99.9%。值得注意的是，这种新方法已成功应用于直接测定药物化合物中的 SMZ。此外，结果表明，SMZ 可以分别与每个 CD 形成 1:1 的超分子化合物。