The defective ribosomal product (DRiP) hypothesis was proposed nearly 25 years ago to account for the rapid generation of peptides from otherwise metabolically stable viral proteins. It posits that errors in converting genetic information into stable proteins accounts for a sizeable fraction of the immunopeptidome. Here, we review recent studies that provide insight into the importance of DRiPs for immunosurveillance and the myriad mechanisms that give rise to DRiPs.

中文翻译：

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DRiPs 得到分子。

近 25 年前提出了有缺陷的核糖体产物 (DRiP) 假说，以解释从其他代谢稳定的病毒蛋白中快速生成肽的原因。它假定将遗传信息转换为稳定蛋白质的错误占免疫肽组的相当大一部分。在这里，我们回顾了最近的研究，这些研究提供了关于 DRiPs 对免疫监视的重要性以及导致 DRiPs 的无数机制的见解。