Protein allostery is a vitally important protein function that has proven to be a vexing problem to understand at the molecular level. Allosteric communication is a hallmark of many protein functions. However, despite more than four decades of study the details regarding allosteric communication in protein systems are still being developed. Engineering of LacI and related homologues to confer alternate allosteric communication has shed light on the pre-requisites for the de novo design of allosteric communication. While the de novo design of an allosteric pathway and complementary functional surfaces has not been realized, this review highlights recent advances that set the stage for true predictive design for a given protein topology.

中文翻译：

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工程变构通信。

蛋白质变构是一种极其重要的蛋白质功能，已被证明是在分子水平上理解的一个棘手问题。变构通讯是许多蛋白质功能的标志。然而，尽管经过了四年多的研究，关于蛋白质系统中变构通讯的细节仍在开发中。LacI 和相关同源物的工程赋予交替变构通信已经阐明了变构通信从头设计的先决条件。虽然变构途径和互补功能表面的从头设计尚未实现，但这篇综述强调了最近的进展，这些进展为给定蛋白质拓扑结构的真正预测设计奠定了基础。