Multifunctional ZnO/SiO2 Core/Shell Nanoparticles for Bioimaging and Drug Delivery Application.,Journal of Fluorescence

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Multifunctional ZnO/SiO2 Core/Shell Nanoparticles for Bioimaging and Drug Delivery Application.
Journal of Fluorescence ( IF 2.6 ) Pub Date : 2020-07-03 , DOI: 10.1007/s10895-020-02578-z
A P S Prasanna ₁ , K S Venkataprasanna ₁ , Balashanmugam Pannerselvam ₂ , Vijayshankar Asokan ₃ , R Sofia Jeniffer ₄ , G Devanand Venkatasubbu ₁

Affiliation

Semiconducting nanoparticles with luminescent properties are used as detection probes and drug carriers in in-vitro and in-vivo analysis. ZnO nanoparticles, due to its biocompatibility and low cost, have shown potential application in bioimaging and drug delivery. Thus, ZnO/SiO₂ core/shell nanoparticle was synthesised by wet chemical method for fluorescent probing and drug delivery application. The synthesised core/shell nanomaterial was characterized using XRD, FTIR, UV-VIS spectroscopy, Raman spectroscopy, TEM and PL analysis. The silicon shell enhances the photoluminescence and aqueous stability of the pure ZnO nanoparticles. The porous surface of the shell acts as a carrier for sustained release of curcumin. The synthesized core/shell particle shows high cell viability, hemocompatibility and promising florescent property.

中文翻译：

用于生物成像和药物输送应用的多功能 ZnO/SiO2 核/壳纳米粒子。

具有发光特性的半导体纳米粒子在体外和体内分析中用作检测探针和药物载体。ZnO 纳米粒子由于其生物相容性和低成本，在生物成像和药物递送方面显示出潜在的应用。因此，ZnO/SiO ₂核/壳纳米粒子是通过湿化学法合成的，用于荧光探测和药物递送应用。使用 XRD、FTIR、UV-VIS 光谱、拉曼光谱、TEM 和 PL 分析对合成的核/壳纳米材料进行了表征。硅壳增强了纯 ZnO 纳米粒子的光致发光和水稳定性。外壳的多孔表面充当姜黄素持续释放的载体。合成的核/壳颗粒显示出高细胞活力、血液相容性和有前途的荧光特性。

更新日期：2020-07-03

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