Biomedical implants tend to induce fibrous encapsulation which can cause malfunction of devices and local discomfort of patients. The purpose of this study was to reduce foreign body-induced fibrous capsule formation by immunomodulation of macrophages. Polyethylene-glycol-grafted liposomes containing phosphatidylserine (PEG-PSLs) were used to modulate macrophages. Mixed cellulose ester (MCE) membranes coated with a PEG-PSLs-entrapped alginate-gelatin matrix were subcutaneously implanted into rats, and the thickness of the fibrous capsule around each MCE membrane was analyzed after four weeks. PEG-PSLs significantly reduced fibrous capsule thickness, while liposomes containing phosphatidylserine (PSLs) did not affect fibrosis. In in vitro assays, PEG-PSLs suppressed TGF-β1 secretion and multinucleated giant cell (MGC) formation in IL-4-treated RAW 264.7, a murine macrophage cell line. Although PSLs inhibited MGC formation, they exerted no effect on the secretion of TGF- β1...

中文翻译：

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通过含有磷脂酰丝氨酸的聚乙二醇接枝脂质体减少纤维包封。

生物医学植入物倾向于诱导纤维包裹，这可能导致设备故障和患者局部不适。本研究的目的是通过巨噬细胞的免疫调节来减少异物诱导的纤维囊形成。含有磷脂酰丝氨酸 (PEG-PSL) 的聚乙二醇接枝脂质体用于调节巨噬细胞。将涂有 PEG-PSLs 包埋的藻酸盐-明胶基质的混合纤维素酯 (MCE) 膜皮下植入大鼠体内，并在 4 周后分析每个 MCE 膜周围的纤维胶囊的厚度。PEG-PSLs 显着降低了纤维囊的厚度，而含有磷脂酰丝氨酸 (PSLs) 的脂质体不影响纤维化。在体外试验中，PEG-PSLs 抑制了 IL-4 处理的 RAW 264.7（一种鼠巨噬细胞系）中 TGF-β1 的分泌和多核巨细胞 (MGC) 的形成。虽然 PSLs 抑制 MGC 的形成，但它们对 TGF-β1 的分泌没有影响...