The rate of adoption of transcatheter aortic valve implantation (TAVI) is increasing rapidly, due to the procedure being less invasive. However, TAVI still faces problems relating to durability, the potential incidence of thrombosis, and the inconvenience of storage in glutaraldehyde (Glut) solution. In this work, a tough hydrogel poly(N-acryloyl glycinamide) (pNAGA) is hybridized with Glut-crosslinked porcine pericardium (Glut-PP) via in situ polymerization and glycerolization, so as to obtain dry leafet material for the fabrication of a pre-mounted bioprosthetic heart valve (BHV). The tensile strength, anti-shearing, and anti-tearing properties of the valve are significantly improved by the process of hydrogel hybridization. Following a period of dry-state compression as a simulation for the crimping process of pre-mounted TAV, pNAGA/Glut-PP showed full recovery without structural damage when fully rehydrated. The introduction of pNAGA also improved the blood compatibil...

中文翻译：

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用于预装 TAVI 瓣膜的坚固 pNAGA 水凝胶杂交猪心包，具有改进的抗撕裂性能和血液相容性。

由于手术侵入性较小，经导管主动脉瓣植入术 (TAVI) 的采用率正在迅速增加。然而，TAVI 仍然面临与耐久性、血栓形成的潜在发生率以及在戊二醛 (Glut) 溶液中储存不便有关的问题。在这项工作中，通过原位聚合和甘油化将坚韧的水凝胶聚（N-丙烯酰甘氨酰胺）（pNAGA）与 Glut 交联的猪心包（Glut-PP）杂交，以获得用于制造预-安装的生物人工心脏瓣膜 (BHV)。水凝胶杂交工艺显着提高了瓣膜的抗拉强度、抗剪切和抗撕裂性能。经过一段时间的干态压缩作为预装 TAV 压接过程的模拟，当完全再水化时，pNAGA/Glut-PP 显示完全恢复而没有结构损伤。pNAGA的引入还提高了血液相容性...