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Synthesis of Nitriles via the Iodine-Mediated Dehydrosulfurization of Thioamides.
Chemical & Pharmaceutical Bulletin ( IF 1.5 ) Pub Date : 2020-01-01 , DOI: 10.1248/cpb.c20-00228
Yuki Murata 1 , Hitomi Iwasa 1 , Mio Matsumura 1 , Shuji Yasuike 1
Affiliation  

A simple general method for the synthesis of nitriles using the inexpensive and easy to handle iodine (I2) is described herein. The reaction of thioamides with I2 in the presence of triethylamine at room temperature under aerobic conditions afforded various nitriles bearing aryl, vinyl, and alkyl groups in good-to-excellent yields. This method was also effective for conversion from thioureas to cyanamides.

中文翻译:

通过碘介导的硫酰胺脱硫反应合成腈。

本文描述了使用廉价且易于处理的碘(I 2)合成腈的简单通用方法。在三乙胺的存在下,在好氧条件下,于三乙胺存在下,硫酰胺与I2的反应以良好至优异的产率得到了带有芳基,乙烯基和烷基的各种腈。该方法对于从硫脲转化为氰胺也是有效的。
更新日期:2020-01-01
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