当前位置: X-MOL 学术Chem. Pharm. Bull. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Syntheses of C2'-Fluorinated Analogs of Solamin.
Chemical & Pharmaceutical Bulletin ( IF 1.5 ) Pub Date : 2020-01-01 , DOI: 10.1248/cpb.c20-00223
Naoto Kojima 1 , Hiromi Hayashi 2 , Hiroki Iwasaki 1 , Masayuki Yamashita 1
Affiliation  

The details of the total syntheses of C2'-fluorinated analogs of solamin, an antitumor annonaceous acetogenin, are described. Fluorine was enantioselectively introduced at the C2'-position by organocatalytic α-fluorination of the aldehyde according to a previously reported method. C2'-fluorinated solamin and its C2'-diastereomer were synthesized by the Sonogashira coupling of a tetrahydrofuran fragment and fluorine-containing γ-lactone fragments.

中文翻译:

Solamin的C2'氟化类似物的合成。

描述了Slamin(一种抗肿瘤的无核产乙酸原素)的C2'氟化类似物的全部合成的详细信息。根据先前报道的方法,通过醛的有机催化α-氟化,将氟对映选择性地引入C 2'位置。通过将四氢呋喃片段和含氟的γ-内酯片段进行Sonogashira偶联,合成了C2'氟化的溶胶蛋白及其C2'-非对映异构体。
更新日期:2020-01-01
down
wechat
bug