The details of the total syntheses of C2'-fluorinated analogs of solamin, an antitumor annonaceous acetogenin, are described. Fluorine was enantioselectively introduced at the C2'-position by organocatalytic α-fluorination of the aldehyde according to a previously reported method. C2'-fluorinated solamin and its C2'-diastereomer were synthesized by the Sonogashira coupling of a tetrahydrofuran fragment and fluorine-containing γ-lactone fragments.

中文翻译：

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Solamin的C2'氟化类似物的合成。

描述了Slamin（一种抗肿瘤的无核产乙酸原素）的C2'氟化类似物的全部合成的详细信息。根据先前报道的方法，通过醛的有机催化α-氟化，将氟对映选择性地引入C 2'位置。通过将四氢呋喃片段和含氟的γ-内酯片段进行Sonogashira偶联，合成了C2'氟化的溶胶蛋白及其C2'-非对映异构体。