Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM.

中文翻译：

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来自面包果皮的树枝和树皮中的黄酮具有抗血浆和抗结核活性。

通过色谱分离法从面包果树枝和树皮中提取丙酮提取物，从而分离出一种新的黄烷酮，lachanochanone（1），以及十一种已知化合物（2-12）。Lakoochanone（1）和moracin C（4）对恶性疟原虫Dd2的抗疟原虫活性较弱，IC50值分别为36.7和33.9 µM。此外，moracin C（4）和sanggenofuran B（5）对A2780细胞系表现出细胞毒活性，其IC50值分别为15.0和57.1 µM。此外，cyclocommunin（7）对结核分枝杆菌H37Ra表现出较强的抗分枝杆菌活性，最低抑菌浓度（MIC）值为12.3 µM。