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Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day.
Neurophotonics ( IF 4.8 ) Pub Date : 2020-06-23 , DOI: 10.1117/1.nph.7.2.025006
Hamoon Zohdi 1 , Felix Scholkmann 1, 2 , Ursula Wolf 1
Affiliation  

Significance: Our study reveals that frontal cerebral oxygenation asymmetry (FCOA), i.e. a difference in the oxygenation between the right and left prefrontal cortex (PFC), is a real phenomenon in healthy human subjects at rest. Aim: To investigate FCOA, we performed a study with 134 healthy right-handed subjects with the systemic physiology augmented functional near infrared spectroscopy (SPA-fNIRS) approach. Approach: Subjects were measured 2 to 4 times on different days resulting in an unprecedented number of 518 single measurements of the absolute values of tissue oxygen saturation ( StO 2 ) and total hemoglobin concentration ([tHb]) of the right and left PFC. Measurements were performed with frequency-domain functional near-infrared spectroscopy. In addition, the cardiorespiratory parameters were measured simultaneously. Results: We found that (i) subjects showed an FCOA (higher StO 2 on the right PFC), but not for tHb; (ii) intrasubject variability was excellent for both StO 2 and tHb, and fair for FCOA; (iii) StO 2 correlated significantly with blood CO 2 concentration, [tHb] with heart rate, respiration rate (RR), and the pulse-respiration quotient (PRQ), and FCOA with RR and PRQ; (iv) FCOA and StO 2 were dependent on season and time of day, respectively; (v) FCOA was negatively correlated with the room temperature; and (vi) StO 2 and tHb were not correlated with the subjects mood but with their chronotype, whereas FCOA was not dependent on the chronotype. Conclusion: Our study demonstrates that FCOA is real, and it provides unique insights into this remarkable phenomenon.

中文翻译:


额叶脑氧合不对称:个体间的变异性和对全身生理学、季节和一天中时间的依赖性。



意义:我们的研究表明,额叶脑氧合不对称(FCOA),即左右前额皮质(PFC)之间的氧合差异,是健康人体受试者在休息时的真实现象。目的:为了研究 FCOA,我们采用系统生理学增强功能近红外光谱 (SPA-fNIRS) 方法对 134 名健康的右手受试者进行了一项研究。方法:在不同的日子对受试者进行 2 至 4 次测量,从而对左右 PFC 的组织氧饱和度 (StO 2 ) 和总血红蛋白浓度 ([tHb]) 的绝对值进行了前所未有的 518 次单次测量。使用频域功能近红外光谱进行测量。此外,同时测量心肺参数。结果:我们发现 (i) 受试者表现出 FCOA(右侧 PFC 较高的 StO 2),但 tHb 没有表现出; (ii) StO 2 和 tHb 的受试者内变异性都非常好,而 FCOA 的受试者内变异性则相当; (iii) StO 2 与血液CO 2 浓度显着相关,[tHb]与心率、呼吸频率(RR)和脉搏呼吸商(PRQ)显着相关,FCOA与RR和PRQ显着相关; (iv) FCOA 和 StO 2 分别取决于季节和一天中的时间; (v) FCOA与室温呈负相关; (vi) StO 2 和 tHb 与受试者的情绪无关,但与他们的时间类型相关,而 FCOA 不依赖于时间类型。结论:我们的研究表明 FCOA 是真实的,并且它为这一非凡现象提供了独特的见解。
更新日期:2020-06-23
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