当前位置: X-MOL 学术Annu. Rev. Cell Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Scaling of Subcellular Structures.
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2020-10-06 , DOI: 10.1146/annurev-cellbio-020520-113246
Wallace F Marshall 1
Affiliation  

As cells grow, the size and number of their internal organelles increase in order to keep up with increased metabolic requirements. Abnormal size of organelles is a hallmark of cancer and an important aspect of diagnosis in cytopathology. Most organelles vary in either size or number, or both, as a function of cell size, but the mechanisms that create this variation remain unclear. In some cases, organelle size appears to scale with cell size through processes of relative growth, but in others the size may be set by either active measurement systems or genetic programs that instruct organelle biosynthetic activities to create organelles of a size appropriate to a given cell type.

中文翻译:


亚细胞结构的缩放。

随着细胞的生长,其内部细胞器的大小和数量也会增加,以满足不断增加的代谢需求。细胞器大小异常是癌症的标志,也是细胞病理学诊断的一个重要方面。大多数细胞器的大小或数量或两者都随着细胞大小的变化而变化,但造成这种变化的机制仍不清楚。在某些情况下,细胞器大小似乎通过相对生长过程与细胞大小成比例,但在其他情况下,大小可能由主动测量系统或遗传程序设定,这些程序指导细胞器生物合成活动以创建适合给定细胞大小的细胞器类型。

更新日期:2020-10-08
down
wechat
bug