Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus, initially speciated as Staphylococcus aureus, that developed from repeated treatment with daptomycin for a complex vascular graft infection. Whole-genome sequencing of longitudinally collected isolates identified acquisition of MprF S337L, a mutation predicted to increase surface charge and repel cationic molecules.

中文翻译：

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复发性金黄色葡萄球菌脓毒症患者达托霉素耐药性的基因组分析。

银色葡萄球菌是一种与侵袭性疾病相关的新型葡萄球菌。我们报告了第一例耐达托霉素/万古霉素的金黄色葡萄球菌，最初被命名为金黄色葡萄球菌，它是由反复使用达托霉素治疗复杂的血管移植感染而发展而来的。纵向收集的分离株的全基因组测序确定了 MprF S337L 的获得，这种突变预计会增加表面电荷并排斥阳离子分子。