Purpose This study evaluated differences and shifting patterns in the health-related quality of life (HRQoL) of 5-year gastric cancer survivors after either a distal subtotal gastrectomy (DSG) or total gastrectomy (TG). Materials and Methods We analyzed the prospectively collected HRQoL data of 528 patients who survived 5 years without recurrence using the European Organization for the Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire and the EORTC Quality of Life Questionnaire-Stomach module according to the type of surgery. The purpose was to identify the proportion of patients with deteriorating HRQoL and to assess the clinical significance of these changes. Results Deteriorating HRQoL was prevalent in both groups, including a large proportion of the DSG group. Decreased overall health status and scores on several function scales were less in the DSG group, while increases on the symptom scales were higher in the TG group. For most of the scales, gaps in HRQoL during the early postoperative period did not merge within the 5 years. Scores on the diarrhea and body image scales revealed “moderate changes” in both groups. Conclusions During the 5-year period after surgery, the TG group suffered from inferior HRQoL compared to the DSG group. However, a large proportion of the DSG group also suffered HRQoL deterioration. In general, the TG group experienced more HRQoL decline, with diarrhea and body image being the major concerns for both groups. To improve HRQoL after gastrectomy, patients must be better informed about post-gastrectomy symptoms. These symptoms must be vigorously investigated, and medical interventions should be available parallel to nutritional support. Favorable evidence of function-preserving gastrectomy should be established and disseminated to improve the HRQoL of early gastric cancer patients.

中文翻译：

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在胃癌长期幸存者的生活质量中，远端胃大部切除术优于全胃切除术

目的 本研究评估了 5 年胃癌幸存者在远端胃大部切除术 (DSG) 或全胃切除术 (TG) 后健康相关生活质量 (HRQoL) 的差异和转变模式。材料和方法 我们使用欧洲癌症研究与治疗组织 (EORTC) 核心生活质量问卷和 EORTC 生活质量问卷-胃模块，分析了前瞻性收集的 528 名存活 5 年且未复发的患者的 HRQoL 数据。手术类型。目的是确定 HRQoL 恶化的患者比例，并评估这些变化的临床意义。结果 恶化的 HRQoL 在两组中都很普遍，包括很大比例的 DSG 组。DSG 组的整体健康状况和几个功能量表的得分下降较少，而 TG 组的症状量表增加较高。对于大多数量表，术后早期 HRQoL 的差距在 5 年内没有合并。腹泻和身体形象量表的分数显示两组都有“中度变化”。结论在术后 5 年期间，TG 组的 HRQoL 低于 DSG 组。然而，很大一部分 DSG 组也遭受 HRQoL 恶化。一般来说，TG 组的 HRQoL 下降更多，腹泻和身体形象是两组的主要关注点。为了改善胃切除术后的 HRQoL，患者必须更好地了解胃切除术后的症状。这些症状一定要认真排查 医疗干预应与营养支持同时提供。应建立和传播保留功能胃切除术的有利证据，以改善早期胃癌患者的 HRQoL。