This study aimed to determine if lactation can be induced by exogenous hormonal treatment in non-pregnant sows. In experiment 1, pseudopregnant animals were divided into four groups and given: 1) 5 mg of estradiol dipropionate (EDP) 5 days before (n = 4), 2) 5 mg of EDP 10 days before (n = 3), 3) 10 mg of EDP 5 days before (n = 3) or 4) 10 mg of EDP 10 days (n = 3) before PGF2α treatment. Artificial lactation was induced in seven pseudopregnant sows (53.8%) by exogenous hormonal treatment. There was no significant effect of either an increased EDP dosage or interval from the EDP treatment to PGF2α treatment on the induction rate of artificial lactation. In experiment 2, milk samples were collected from artificial lactating and natural lactating sows (n = 6). IgG and IgA levels in the milk collected from both groups were significantly associated with time during the experimental period. Milk IgG levels 24 h after PGF2α treatment in artificial lactating sows were higher than those in the colostrum of lactating sows. In experiment 3, hormonal profiles in pseudopregnant sows with (n = 3) or without (n = 3) EDP treatment were determined. There was a significant difference in estradiol-17β levels on days 8, 7 and 5 before PGF2α treatment between groups. Progesterone and prolactin concentrations did not differ between groups. The present study revealed for the first time that lactation could be induced by exogenous hormonal treatment in non-pregnant sows and that the milk collected from these sows contained high immunoglobulin levels.

中文翻译：

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非妊娠母猪外源激素治疗人工泌乳


本研究旨在确定非妊娠母猪是否可以通过外源激素治疗诱导泌乳。在实验1中，假孕动物被分为四组并给予：1）5毫克二丙酸雌二醇（EDP）5天前（n = 4），2）5毫克EDP前10天（n = 3），3）在 PGF2α 治疗前 5 天（n = 3）服用 10 mg EDP 或 4）在 PGF2α 治疗前 10 天（n = 3）服用 10 mg EDP。通过外源激素治疗对七头假孕母猪（53.8%）进行人工泌乳。增加EDP剂量或EDP治疗与PGF2α治疗之间的时间间隔对人工泌乳的诱导率没有显着影响。在实验2中，从人工泌乳母猪和自然泌乳母猪（n = 6）中采集牛奶样品。从两组收集的乳汁中 IgG 和 IgA 水平与实验期间的时间显着相关。人工泌乳母猪PGF2α处理后24小时乳汁IgG水平高于泌乳母猪初乳。在实验 3 中，确定了经过 (n = 3) 或未经 (n = 3) EDP 处理的假孕母猪的激素分布。 PGF2α治疗前第8、7和5天各组之间的雌二醇-17β水平存在显着差异。孕酮和催乳素浓度在各组之间没有差异。本研究首次揭示，非怀孕母猪可以通过外源激素治疗诱导泌乳，并且从这些母猪收集的牛奶中含有高水平的免疫球蛋白。