Oxidative stress has been considered as a contributory aspect for major complications of diabetes mellitus consisting of diabetic nephropathy. This study aimed to examine the therapeutic effect of formononetin in streptozotocin (STZ)-induced diabetic nephropathy through measuring biochemical parameters, oxidative indicators, and histopathological examination of renal tissues. Administration of a dose of STZ (55 mg/kg of body weight) intraperitoneal induced diabetic nephropathy in rats as indicated by an increase in serum glucose, creatinine, triglyceride, cholesterol, and BUN levels related to the depletion of serum albumin level. Besides, STZ treatment led to the depletion of antioxidant enzymes together with superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). Administration of formononetin at the dose of 10, 20, and 40 mg/kg extensively decreased biochemical parameters with a rise in serum albumin level. Formononetin was observed to improved antioxidant enzyme ranges and offered protection against lipid peroxidation (LPO). STZ administered rats show an elevated level of TNF-α and IL-6. Meanwhile, formononetin-treated rats inhibited the elevated level of cytokine. This study concluded that formononetin may additionally modulate oxidative stress and protected renal tissues from STZ injury. It also showed improvement in renal histopathological architecture in STZ-induced diabetic nephropathy.

中文翻译：

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福乐莫宁可能预防链脲佐菌素诱发的糖尿病性肾病的抗氧化能力

氧化应激被认为是由糖尿病性肾病组成的糖尿病主要并发症的重要原因。这项研究旨在通过测量生化参数，氧化指标和肾脏组织的病理学检查来检查福乐敏在链脲佐菌素（STZ）诱导的糖尿病性肾病中的治疗作用。血清中葡萄糖，肌酐，甘油三酸酯，胆固醇和BUN的升高与血清白蛋白水平的降低有关，表明在大鼠腹腔内诱导剂量的STZ（55 mg / kg体重）可导致糖尿病性肾病。此外，STZ处理导致抗氧化剂酶，超氧化物歧化酶（SOD），谷胱甘肽（GSH）和过氧化氢酶（CAT）的消耗。以10、20，和40 mg / kg的生物化学参数大大降低，血清白蛋白水平升高。观察到Formononetin改善了抗氧化酶的范围，并提供了针对脂质过氧化（LPO）的保护。给予STZ的大鼠显示TNF-α和IL-6水平升高。同时，用formononetin处理的大鼠抑制了细胞因子的升高。这项研究得出的结论是，formononetin可能还调节氧化应激并保护肾脏组织免受STZ损伤。它还显示出STZ诱导的糖尿病肾病的肾脏组织病理学结构改善。经formononetin处理的大鼠抑制了细胞因子水平的升高。这项研究得出的结论是，formononetin可以额外调节氧化应激并保护肾脏组织免受STZ损伤。它还显示出STZ诱导的糖尿病肾病的肾脏组织病理学结构改善。经formononetin处理的大鼠抑制了细胞因子水平的升高。这项研究得出的结论是，formononetin可能还调节氧化应激并保护肾脏组织免受STZ损伤。它还显示出STZ诱导的糖尿病肾病的肾脏组织病理学结构改善。