The heterocyclic compounds are extremely important with wide array of synthetic, pharmaceutical, and industrial applications. Heterocyclic-containing compounds have been reported for their broad spectrum of biological activities including antibacterial, antifungal, antiviral, antiprotozoal, and anthelmintic activity. Several techniques have been used for the quantitation of heterocyclic compounds in pharmaceutical samples such as high-performance liquid chromatography (HPLC) either equipped with UV-visible or fluorescence, in addition to liquid chromatography-mass spectroscopy, UV-visible spectrophotometry, and electrochemical techniques. This article reviewed several published methods that have been applied to detect and quantify some pharmaceutical drugs containing heterocyclic compounds focusing on four drugs: brinzolamide, timolol maleate, flumethasone pivalate, and clioquinol. From literature reviews, HPLC is the most widely used analytical technique for the quantitative analysis of the four selected drugs.

中文翻译：

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对一些含有杂环的药用化合物的分析研究的综述：苯唑酰胺，马来酸替莫洛尔，新戊酸氟美松和氯喹诺

在广泛的合成，制药和工业应用中，杂环化合物极为重要。据报道，含杂环化合物具有广泛的生物学活性，包括抗菌，抗真菌，抗病毒，抗原生动物和驱虫活性。除液相色谱-质谱，紫外可见分光光度法和电化学技术外，几种技术还用于定量药物样品中的杂环化合物，例如配备有紫外可见或荧光的高效液相色谱（HPLC） 。本文回顾了几种已发布的方法，这些方法已被用于检测和定量一些含有杂环化合物的药物，这些药物主要针对四种药物：苯佐胺，马来酸噻吗洛尔，氟甲松新戊酸酯和氯喹醇。从文献综述来看，HPLC是对四种选定药物进行定量分析的最广泛使用的分析技术。