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Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-12 , DOI: 10.1021/acs.orglett.0c02398 Clarence T T Wong 1 , Jacky C H Chu 1 , Summer Y Y Ha 1 , Roy C H Wong 1 , Gaole Dai 1 , Tsz-Tung Kwong 2 , Chi-Hang Wong 2 , Dennis K P Ng 1
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-12 , DOI: 10.1021/acs.orglett.0c02398 Clarence T T Wong 1 , Jacky C H Chu 1 , Summer Y Y Ha 1 , Roy C H Wong 1 , Gaole Dai 1 , Tsz-Tung Kwong 2 , Chi-Hang Wong 2 , Dennis K P Ng 1
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A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.
中文翻译：
酞菁胺的生物缀合和固定化酞菁胺的捕获反应。
已合成了可以与多种生物分子（包括肽，单糖，脂质和DNA）缀合的邻苯二甲醛取代的酞菁，并使用通用且有效的邻苯二甲醛-胺捕获技术将其固定在牛血清册纳米颗粒和载玻片的表面上反应。后两种材料的光诱导的细胞毒性作用也已分别针对癌细胞和细菌进行了研究，表明它们是用于光动力疗法的高效光敏系统。
更新日期：2020-09-20
中文翻译：
酞菁胺的生物缀合和固定化酞菁胺的捕获反应。
已合成了可以与多种生物分子（包括肽，单糖，脂质和DNA）缀合的邻苯二甲醛取代的酞菁，并使用通用且有效的邻苯二甲醛-胺捕获技术将其固定在牛血清册纳米颗粒和载玻片的表面上反应。后两种材料的光诱导的细胞毒性作用也已分别针对癌细胞和细菌进行了研究，表明它们是用于光动力疗法的高效光敏系统。
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