Adipogenesis is the process through which preadipocytes differentiate into adipocytes. During this process, the preadipocytes cease to proliferate, begin to accumulate lipid droplets, and develop morphologic and biochemical characteristics of mature adipocytes. Mesenchymal stem cells (MSCs) are a type of adult stem cells known for their high plasticity and capacity to generate mesodermal and nonmesodermal tissues. Many mature cell types can be generated from MSCs, including adipocyte, osteocyte, and chondrocyte. The differentiation of stem cells into multiple mature phenotypes is at the basis for tissue regeneration and repair. Cancer stem cells (CSCs) play a very important role in tumor development and have the potential to differentiate into multiple cell lineages. Accumulating evidence has shown that cancer cells can be induced to differentiate into various benign cells, such as adipocytes, fibrocytes, osteoblast, by a variety of small molecular compounds, which may provide new strategies for cancer treatment. Recent studies have reported that tumor cells undergoing epithelial-to-mesenchymal transition can be induced to differentiate into adipocytes. In this review, molecular mechanisms, signal pathways, and the roles of various biological processes in adipose differentiation are summarized. Understanding the molecular mechanism of adipogenesis and adipose differentiation of cancer cells may contribute to cancer treatments that involve inducing differentiation into benign cells.

中文翻译：

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干细胞分化为脂肪细胞的分子机制和恶性肿瘤的脂肪细胞分化。

脂肪生成是前脂肪细胞分化为脂肪细胞的过程。在此过程中，前脂肪细胞停止增殖，开始积累脂质液滴，并发展出成熟脂肪细胞的形态和生化特征。间充质干细胞（MSCs）是一种成年干细胞，以其高可塑性和产生中胚层和非中胚层组织的能力而闻名。MSC可产生许多成熟的细胞类型，包括脂肪细胞，骨细胞和软骨细胞。干细胞向多种成熟表型的分化是组织再生和修复的基础。癌症干细胞（CSC）在肿瘤发展中起着非常重要的作用，并且有可能分化为多种细胞谱系。越来越多的证据表明，各种小分子化合物可以诱导癌细胞分化为各种良性细胞，例如脂肪细胞，纤维细胞，成骨细胞，这可能为癌症治疗提供新的策略。最近的研究已经报道，经历上皮到间充质转变的肿瘤细胞可以被诱导分化为脂肪细胞。在这篇综述中，总结了分子机制，信号通路以及各种生物过程在脂肪分化中的作用。了解癌细胞脂肪形成和脂肪分化的分子机制可能有助于癌症治疗，包括诱导分化为良性细胞。这可能为癌症治疗提供新的策略。最近的研究报道，可以诱导经历上皮-间质转化的肿瘤细胞分化为脂肪细胞。在这篇综述中，总结了分子机制，信号通路以及各种生物过程在脂肪分化中的作用。了解癌细胞脂肪形成和脂肪分化的分子机制可能有助于癌症治疗，包括诱导分化为良性细胞。这可能为癌症治疗提供新的策略。最近的研究报道，可以诱导经历上皮-间质转化的肿瘤细胞分化为脂肪细胞。在这篇综述中，总结了分子机制，信号通路以及各种生物过程在脂肪分化中的作用。了解癌细胞脂肪形成和脂肪分化的分子机制可能有助于癌症治疗，包括诱导分化为良性细胞。