Abstract

Malassezia restricta and Malassezia globosa are lipid dependent commensal yeasts associated with dandruff. Antifungal actives such as zinc pyrithione are commonly used in antidandruff shampoos, although their efficacy is not clearly demonstrated. In this study, we assessed the efficacy of antifungal treatments on scalp Malassezia via a combination of culturomic and genomic detection methods. Zinc pyrithione inhibited Malassezia growth at low minimum inhibitory concentrations (MICs). In a longitudinal pilot study, quantitative polymerase chain reaction (qPCR) analysis showed a decrease in M. restricta on the scalp after zinc pyrithione treatment. These findings validate the antifungal efficacy of zinc pyrithione as a dandruff treatment.

Lay Abstract

Malassezia yeasts are associated with dandruff and seborrheic dermatitis. Zinc pyrithione is effective against Malassezia growth in vitro and when tested on human skin as a shampoo. These findings will be useful for investigating the role of Malassezia in skin microbiome intervention studies.

中文翻译：

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吡啶硫酮锌洗发水对皮肤共生马拉色菌的影响

摘要

限制性马拉色菌和球形马拉色菌是与头皮屑相关的脂质依赖性共生酵母。抗真菌活性物质如吡啶硫酮锌通常用于去头屑洗发水，尽管它们的功效尚未得到明确证明。在这项研究中，我们通过培养组学和基因组检测方法的组合评估了抗真菌治疗对头皮马拉色菌的疗效。吡啶硫酮锌在低最小抑制浓度 (MIC) 下抑制马拉色菌生长。在纵向试点研究中，定量聚合酶链反应 (qPCR) 分析显示限制性分枝杆菌减少吡啶硫酮锌治疗后的头皮上。这些发现证实了吡啶硫酮锌作为头皮屑治疗的抗真菌功效。

摘要

马拉色菌与头皮屑和脂溢性皮炎有关。吡啶硫酮锌在体外和作为洗发水在人体皮肤上测试时可有效抑制马拉色菌的生长。这些发现将有助于调查马拉色菌在皮肤微生物组干预研究中的作用。