Abstract

Candida albicans is a pathogenic fungus that causes deep mycosis in immunocompromised patients and forms a biofilm on catheter surfaces. Here we showed that C. albicans infection of silkworms led to biofilm formation on the surface of polyurethane fibers, a catheter substrate material, while inside the silkworm body. Silkworms inserted with polyurethane fibers survived for at least 48 hours. When silkworms inserted with polyurethane fibers were subsequently infected with C. albicans, biofilm formed on the surface of the polyurethane fiber within 24 hours in the silkworm body. These results suggest that silkworms can be used to evaluate C. albicans biofilm formation.

中文翻译：

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评估家蚕中白色念珠菌生物膜的形成

摘要

白色念珠菌是一种致病真菌，可导致免疫功能低下患者发生深部真菌病，并在导管表面形成生物膜。在这里，我们展示了蚕的白色念珠菌感染导致在聚氨酯纤维表面形成生物膜，聚氨酯纤维是一种导管基底材料，而在蚕体内。插入聚氨酯纤维的蚕至少存活了 48 小时。当插入聚氨酯纤维的蚕随后被白色念珠菌感染时，24小时内在蚕体内的聚氨酯纤维表面形成生物膜。这些结果表明，蚕可用于评估白色念珠菌生物膜的形成。