Abstract

Purpose

To investigate the follow-up strategy of stage II NPC based on event dynamics.

Methods

Stage II NPC patients were retrospectively assessed from January 2007 to December 2014 at Guangxi Medical University Cancer Hospital. Event dynamics for patterns of recurrence and metastasis were calculated based on the hazard rates.

Results

A total of 251 patients were included. After treatment, 10 (4.0%) patients developed recurrence and 6 (2.4%) patients developed metastasis. The hazard rate curve of recurrence showed a bimodal recurrence pattern. The maximum hazard rates were 0.048 and 0.072 at the intervals of 36–42 and 90–96 months, respectively. The maximum hazard rate was 0.036 at the interval of 48–54 months in the hazard rate curve of metastasis.

Conclusions

Follow-up strategies of stage II NPC should be performed based on currently recommended guidelines. In the future, it should be modified to meet the needs of individual patients.

中文翻译：

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基于事件动态的II期鼻咽癌随访策略。

摘要

目的

调查基于事件动态的第二阶段NPC的后续策略。

方法

从2007年1月至2014年12月在广西医科大学肿瘤医院对II期NPC患者进行回顾性评估。根据危险率计算复发和转移模式的事件动态。

结果

总共包括251位患者。治疗后，有10（4.0％）例复发，6（2.4％）例转移。复发的危险率曲线显示出双峰复发模式。在36-42和90-96个月的间隔内，最大危害率分别为0.048和0.072。在转移的风险率曲线中，在48–54个月的间隔内，最大风险率为0.036。

结论

II期NPC的随访策略应根据当前推荐的指南进行。将来，应对其进行修改以满足个别患者的需求。