Abstract

Purpose

This study aimed to compare the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) for hepatocellular carcinoma (HCC) adjacent to large vessels with those far from large vessels.

Methods

The clinical data of patients who underwent ultrasound-guided percutaneous MWA for HCC were retrospectively analyzed between January 2011 and December 2018 in Shengjing Hospital. Patients with HCC adjacent to large vessels were included in the Vessel group, the remaining patients were included in the Control group. Propensity score matching analysis was used to reduce confounding bias. The rates of complete ablation, local recurrence, recurrence-free survival (RFS), overall survival (OS) and complications were compared between the two groups.

Results

A total of 134 patients with 157 nodules (size range, 0.6–3.8 cm) were enrolled in this study, 23 in the Vessel group and 111 in the Control group. A total of 21 patients in the Vessel group (91.3%) and 105 patients in the Control group (94.6%) achieved complete ablation (p = .902). Following 1:2 propensity score matching, 22 patients were included in the Vessel group and 40 patients were enrolled in the Control group. Local recurrence was observed in 2 (9.1%) patients in the Vessel group and 5 (12.5%) in the Control group (p = .86). No significant difference in local recurrence rate, RFS and OS were observed between the two groups.

Conclusions

Ultrasound-guided percutaneous MWA appears to be a safe procedure and can achieve comparable oncological efficacy for HCC abutting large vessels.

中文翻译：

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超声引导下经皮微波消融治疗邻近大血管的肝细胞癌：倾向评分匹配分析。

摘要

目的

这项研究旨在比较超声引导下经皮微波消融（MWA）对邻近大血管的肝细胞癌（HCC）和远离大血管的肝癌（HCC）的疗效和安全性。

方法

回顾性分析了2011年1月至2018年12月在盛京医院接受超声引导的经皮MWA治疗HCC患者的临床资料。邻近大血管的HCC患者归入血管组，其余患者归入对照组。倾向得分匹配分析用于减少混杂偏差。比较两组的完全消融率，局部复发率，无复发生存率（RFS），总生存率（OS）和并发症发生率。

结果

本研究共入选134例157个结节（大小范围0.6-3.8 cm）的患者，血管组23例，对照组111例。血管组中共有21例患者（占91.3％），对照组中有105例患者（占94.6％）实现了完全消融（p  = .902）。在按1：2的倾向评分匹配后，血管组包括22例患者，对照组为40例。在血管组中有2例（9.1％）患者出现局部复发，在对照组中有5例（12.5％）（p  = .86）。两组之间的局部复发率，RFS和OS没有显着差异。

结论

超声引导的经皮MWA似乎是一种安全的方法，对于与大血管邻接的HCC，可以达到相当的肿瘤学疗效。