ABSTRACT

Refractory wounds can be a serious threat to the quality of life and survival of patients. Various surgical methods have been attempted; however, they do not cure these refractory wounds; therefore, new and promising treatment methods to improve wound healing and angiogenesis are urgently warranted. Adipose-derived stromal vascular fraction (SVF) cells have been clinically used to promote healing. Hence, we aimed to evaluate the clinical efficacy of SVF cells for the treatment of refractory wounds. Forty patients with refractory wounds were randomly divided into two groups: patients in the experimental group were treated with SVFs (n = 20) and those in the control group were given conventional treatment (n = 20). The general data of age, sex ratio, wound size, frequency of every caused wound, and etiology were compared between the two groups. No significant difference was found between the two groups (P = 0.089). Clinical efficacy was also evaluated between the two groups. The experimental group had a shorter wound healing time and a significantly higher healing rate than the control group (P = 0.023 and P = 0.035, respectively). Therefore, SVFs may be a new and effective treatment for refractory wounds (P = 0.043).

摘要

难治性伤口可能严重威胁患者的生活质量和生存。已经尝试了多种外科手术方法。但是，它们不能治愈这些难治性伤口。因此，迫切需要新的有前途的治疗方法来改善伤口愈合和血管生成。脂肪来源的基质血管分数（SVF）细胞已被临床用于促进愈合。因此，我们旨在评估SVF细胞治疗难治性伤口的临床疗效。40例难治性伤口患者随机分为两组：实验组患者接受SVFs治疗（n = 20），对照组给予常规治疗（n = 20）。比较两组的年龄，性别比，伤口大小，每一次造成伤口的频率和病因等一般数据。P  = 0.089）。还评估了两组之间的临床疗效。实验组的伤口愈合时间短于对照组，治愈率明显高于对照组（分别为P  = 0.023和P  = 0.035）。因此，SVF可能是治疗难治性伤口的一种新的有效方法（P  = 0.043）。