Frontiers in Molecular Biosciences ( IF 3.9 ) Pub Date : 2020-07-23 , DOI: 10.3389/fmolb.2020.00198 Ping Bai 1, 2, 3 , Yu Lan 2 , Hao Wang 2 , Zude Chen 2 , Stephanie Fiedler 2 , Robin Striar 2 , Xiaoxia Lu 1 , Changning Wang 2
Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human diseases. The non-invasive imaging technique, such as positron emission tomography (PET), provides a powerful tool to visualize and quantify the BET family proteins that accelerating the investigation of this domain. Herein, we describe the development of a promising PET probe,
中文翻译:
针对溴域和末端域(BET)家族蛋白的新型正电子发射断层扫描(PET)放射性示踪剂的开发。
溴结构域和末端外结构域(BET)家族蛋白由于与人类疾病的密切关系而成为研究的热点。非侵入性成像技术,例如正电子发射断层扫描(PET),提供了强大的工具来可视化和量化BET家族蛋白,从而加速了对该域的研究。在此,我们描述了有前途的PET探针的开发,