Abstract

A practical and efficient method for the synthesis of alcohols in one pot from readily available alkynes via a tandem process by formic acid promoted hydration and metal-ligand bifunctional iridium-catalyzed­ transfer hydrogenation under mild conditions has been described. This transformation is simple, efficient, and can be performed with a variety of alkynes in good yields and with excellent stereoselectivities. Experimental results showed high catalytic activity, and turnover frequency (TOF) up to 25000. Importantly, this transformation can be conducted in water, and is thus green and environmentally friendly.

中文翻译：

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高效水合炔烃的加氢和串联转移加氢

摘要

已经描述了在温和的条件下通过甲酸促进水合和金属-配体双官能铱催化的转移加氢通过串联方法在一锅中从容易获得的炔烃合成醇的实用而有效的方法。这种转化是简单，有效的，并且可以用多种炔烃以高收率和优异的立体选择性进行。实验结果表明，该催化剂具有很高的催化活性，周转频率（TOF）高达25000。重要的是，这种转化可以在水中进行，因此绿色环保。