An efficient green synthesis and antibacterial activity of 1,3‐benzoxazine and 1,3‐naphthoxazine using NaCl.SiO2 as solid catalyst in neat condition,Journal of Heterocyclic Chemistry

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An efficient green synthesis and antibacterial activity of 1,3‐benzoxazine and 1,3‐naphthoxazine using NaCl.SiO2 as solid catalyst in neat condition
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-08-12 , DOI: 10.1002/jhet.4059
Putusenla Imchen ₁ , Betokali K. Zhimomi ₁ , Lensayula Longkumer ₁ , Shokip Tumtin ₂ , Toka Swu ₃ , Tovishe Phucho ₁

Affiliation

A series of 1,3‐oxazine derivatives were synthesized by a one‐pot three‐component (ie, phenol, formaldehyde, amine) method where SiO₂ bonded with NaCl was used as a reusable, more efficient, easily prepared, and available solid catalyst. The reactions were also carried out at room temperature for greener approach. in vitro studies for the synthesized compounds were also done against two gram‐positive (Bacillus subtilis and Staphylococcus aureus) and two gram‐negative bacteria (Escherichia coli and Klebsiella pneumonia) to check for their applicability as an antibacterial agent where some of the synthesized compounds gives the best antibacterial activity against selected bacterial strains. Streptomycin was used as a standard control for all the microbial test.

中文翻译：

以NaCl.SiO2为固体催化剂，在纯净条件下有效地绿色合成1,3-苯并恶嗪和1,3-萘恶嗪

通过单锅三组分（即苯酚，甲醛，胺）方法合成了一系列1,3-恶嗪衍生物，其中与NaCl结合的SiO ₂被用作可重复使用，更有效，易于制备且可用的固体催化剂。为了更绿色的方法，反应也在室温下进行。还针对两种革兰氏阳性（枯草芽孢杆菌和金黄色葡萄球菌）和两种革兰氏阴性细菌（大肠杆菌和肺炎克雷伯氏菌）进行了合成化合物的体外研究。）以检查其作为抗菌剂的适用性，其中某些合成的化合物对选定的细菌菌株具有最佳的抗菌活性。链霉素被用作所有微生物测试的标准对照。

更新日期：2020-09-08

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