Light-Driven Proton Transfer for Cyclic and Temporal Switching of Enzymatic Nanoreactors.,Small

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Light-Driven Proton Transfer for Cyclic and Temporal Switching of Enzymatic Nanoreactors.
Small ( IF 13.0 ) Pub Date : 2020-08-11 , DOI: 10.1002/smll.202002135
Silvia Moreno ₁ , Priyanka Sharan _{1,

2,

3} , Johanna Engelke _{1,

2} , Hannes Gumz _{1,

4} , Susanne Boye ₁ , Ulrich Oertel ₁ , Peng Wang _{1,

2} , Susanta Banerjee ₃ , Rafal Klajn ₅ , Brigitte Voit _{1,

2,

4} , Albena Lederer _{1,

2,

6} , Dietmar Appelhans ₁

Affiliation

Temporal activation of biological processes by visible light and subsequent return to an inactive state in the absence of light is an essential characteristic of photoreceptor cells. Inspired by these phenomena, light‐responsive materials are very attractive due to the high spatiotemporal control of light irradiation, with light being able to precisely orchestrate processes repeatedly over many cycles. Herein, it is reported that light‐driven proton transfer triggered by a merocyanine‐based photoacid can be used to modulate the permeability of pH‐responsive polymersomes through cyclic, temporally controlled protonation and deprotonation of the polymersome membrane. The membranes can undergo repeated light‐driven swelling–contraction cycles without losing functional effectiveness. When applied to enzyme loaded‐nanoreactors, this membrane responsiveness is used for the reversible control of enzymatic reactions. This combination of the merocyanine‐based photoacid and pH‐switchable nanoreactors results in rapidly responding and versatile supramolecular systems successfully used to switch enzymatic reactions ON and OFF on demand.

中文翻译：

光驱动质子转移，用于酶促纳米反应器的循环和时间转换。

可见光对生物过程的暂时激活并随后在不存在光的情况下恢复为非活性状态是感光细胞的基本特征。受这些现象的启发，由于对光辐射的高度时空控制，光响应材料非常有吸引力，并且光能够在多个周期内精确地精确地编排过程。在此，据报道，由基于花菁的光酸引发的光驱动质子转移可用于通过周期性，时间控制的质体膜质子化和去质子化来调节pH响应性质体的渗透性。膜可以经历重复的光驱动溶胀-收缩循环，而不会失去功能有效性。当应用于负载酶的纳米反应器时，这种膜反应性用于酶反应的可逆控制。基于花菁的光致酸和可调节pH值的纳米反应器的结合，可产生快速响应的通用超分子系统，成功地用于按需打开和关闭酶促反应。

更新日期：2020-09-18

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