Poly(glycerol sebacate) (PGS) is an attractive polymer that has many applications in medical fields, especially in tissue engineering. In this study, the influence of solvent system on electrospinnability, forming of bead‐free nanofibers and the morphology of PGS nanofibers was investigated and discussed. Among different solvents, the acidic solvent as a benign solvent was used for electrospinning. The steps were as follows: (a) Synthesis the PGS pre‐polymer and analysis its chemical structure by Fourier‐transform infrared spectroscopy (FTIR); (b) Electrospinning of the PGS by mixing PCL in eight different solvent systems; (c) evaluation the morphology of produced nanofibers using the scanning electron microscope (SEM); (d) the study of biocompatibility of produced nanofibers by MTT assay. The average diameter of nanofibers in different solvent systems turned out to vary from 260 ± 63 to 4588 ± 970 nm and nanofibers with different morphologies were produced by changing the solvent system. Among the produced straight nanofibers, the best samples were FA_30,15 (formic acid), FA/AC_30,15 (formic acid/Acetone), FA/AA_30,15 (formic acid/acetic acid), CF/DMF_20,15 (chloroform/N,N‐dimethylformamide), FA/AA_35,15, and CF/DMF_23,15, respectively (based on size and morphology). Also, the produced nanofibers in CF/ET (chloroform/ethanol) had a rough surface. When AA was used as solvent and polymer concentration was kept 35% w/v, sponge‐like scaffold was produced. Moreover, spring‐like nanofibers were fabricated by using DMF, (at 30% w/v) and AC (in all polymer concentrations). MTT results also demonstrated that CF/DMF_20,15 as produced sample via hazardous solvents (class 3) is biocompatible. These scaffolds can be used in different tissue engineering applications according to their morphology.

中文翻译：

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电纺PGS / PCL纳米纤维：从直形到海绵状和类似弹簧的形态

聚癸二酸甘油酯（PGS）是一种有吸引力的聚合物，在医学领域，尤其是组织工程领域具有许多应用。在这项研究中，研究和讨论了溶剂体系对电纺丝性，无珠纳米纤维形成和PGS纳米纤维形态的影响。在不同的溶剂中，将酸性溶剂作为良性溶剂用于静电纺丝。步骤如下：（a）合成PGS预聚物，并通过傅里叶变换红外光谱（FTIR）分析其化学结构；（b）通过在八种不同的溶剂系统中混合PCL来进行PGS的静电纺丝；（c）使用扫描电子显微镜（SEM）评估所生产的纳米纤维的形态；（d）通过MTT分析研究生产的纳米纤维的生物相容性。纳米纤维在不同溶剂体系中的平均直径在260±63至4588±970 nm之间变化，并且通过改变溶剂体系可以生产出具有不同形态的纳米纤维。在生产的直纳米纤维中，最好的样品是FA_30,15（甲酸），FA / AC _30,15（甲酸/丙酮），FA / AA _30,15（甲酸/乙酸），CF / DMF _20,15（氯仿/ N，N-二甲基甲酰胺） ，FA / AA _35,15和CF / DMF _23,15（基于大小和形态）。另外，在CF / ET（氯仿/乙醇）中制得的纳米纤维具有粗糙的表面。当使用AA作为溶剂并且聚合物浓度保持在35％w / v时，就产生了海绵状支架。此外，弹簧状纳米纤维是使用DMF（30％w / v）和AC（在所有聚合物浓度下）制成的。MTT结果还表明CF / DMF _20,15通过危险溶剂（第3类）生产的样品具有生物相容性。根据其形态，这些支架可用于不同的组织工程应用中。