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Synthesis of Novel Cyclic Nitrones with gem‐Difluoroalkyl Side Chains Through Cascade Reactions
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-08-12 , DOI: 10.1002/ejoc.202000972
Ali Souleiman 1 , Rima Ibrahim 2 , Zeinab Barakat 2 , Nicolas Gouault 3 , Thierry Roisnel 4 , Joel Boustie 5 , Rene Gree 6 , Ali Hachem 7
Affiliation  

New mono‐ and bicyclic nitrones containing a CF2 group have been efficiently synthetized starting from propargylic fluorides. The key steps involve isomerization of propargylic alcohols to enones, followed by nucleophilic addition of nitro alkane anions and then intramolecular Michael additions. The last step is a reductive cyclisation from the nitro group.
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中文翻译:

级联反应合成具有二氟烷基侧链的新型环硝基

从炔丙基氟化物开始,已经有效地合成了含有CF 2基团的新的单环和双环硝酮。关键步骤包括将炔丙醇异构化为烯酮,然后进行硝基链烷阴离子的亲核加成,然后进行分子内迈克尔加成。最后一步是从硝基还原环化。
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更新日期:2020-09-15
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