Cell-Free Exploration of the Natural Product Chemical Space.,ChemBioChem

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Cell-Free Exploration of the Natural Product Chemical Space.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-08-11 , DOI: 10.1002/cbic.202000452
Jonathan W Bogart _{1,

2,

3} , Maria D Cabezas _{1,

2,

3} , Bastian Vögeli _{1,

2,

3} , Derek A Wong _{1,

2,

3} , Ashty S Karim _{1,

2,

3} , Michael C Jewett _{1,

2,

3,

4,

5}

Affiliation

Our advancing bioinformatic capabilities and enzymological knowledge are shifting the bottleneck in natural product discovery from identification to expression. The complementary cell‐free and in vitro technologies reviewed herein provide a means to close this gap and rapidly explore natural product chemical space.