Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?: A potential explanation for much of the novel coronavirus' distinctive genome.,BioEssays

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Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?: A potential explanation for much of the novel coronavirus' distinctive genome.
BioEssays ( IF 3.2 ) Pub Date : 2020-08-12 , DOI: 10.1002/bies.202000091
Karl Sirotkin ₁ , Dan Sirotkin ₁

Affiliation

Despite claims from prominent scientists that SARS‐CoV‐2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy‐makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual‐use gain‐of‐function research practice of viral serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS‐CoV‐2's distinctive spike‐protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re‐examination of the risks and rewards of dual‐use gain‐of‐function research.

中文翻译：

Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?：对新型冠状病毒大部分独特基因组的潜在解释。

尽管著名科学家声称 SARS-CoV-2 无疑是自然出现的，但这种新型冠状病毒的病因学仍然是一个紧迫且悬而未决的问题：在不了解疾病的真正性质的情况下，临床医生不可能适当地制定他们的护理方案，以制定政策。 ‐制造商正确评估威胁的性质和程度，并让公众适当地改变他们的行为。除非确定了完成自然人畜共患跳跃所需的中间宿主，否则病毒连续传代的双重用途功能获得研究实践应被视为新型冠状病毒产生的可行途径。连续传代的做法模仿了自然的人畜共患跳跃，并为 SARS-CoV-2 独特的刺突蛋白区域及其与血管紧张素转换酶 (ACE2) 的意外高亲和力以及其中值得注意的多碱性弗林蛋白酶切割位点提供了解释。其他分子线索提出了进一步的问题，所有这些都需要对新型冠状病毒的起源进行全面调查，并重新审视双重用途功能获得研究的风险和回报。

更新日期：2020-09-24

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