A facile and efficient method for construction of S-CF₂ or O-CF₂ bonds through intermolecular radical nucleophilic substitution (S_RN1) reaction of 2-bromo-2,2-difluoro-N-phenylacetamide and thiophenols or phenols was developed, which has also been successfully utilized in the intramolecular S_RN1 reaction to generate a new O-CF₂ bonds for synthesis of biologically important 2,2-difluoro-2H-benzo [1,4]oxazin-3-one. The protocol enables an efficient access to gem-difluoromethylene-containing thioethers or ethers and oxazin heterocycles with good to excellent yields by inter/intramolecular radical nucleophilic substitution reaction under mild reaction conditions.

开发了一种通过2-溴-2,2-二氟-N-苯基乙酰胺与硫酚或酚的分子间自由基亲核取代（S _RN 1）反应构建S-CF ₂或O-CF ₂键的简便有效方法，它也已成功地用于分子内S _RN 1反应中，以生成新的O-CF ₂键，用于合成生物学上重要的2,2-二氟-2H-苯并[1,4]恶嗪-3-酮。该协议可以有效访问gem在温和的反应条件下，通过分子间/分子间自由基亲核取代反应，具有良好的优良产率的含-二氟亚甲基的硫醚或醚和恶嗪杂环。