Poly(ester amide)s (PEAs) have developed in current years as a vital class of synthetic biodegradable materials with specialty applications in various fields. These PEAs provide both amide and ester groups in their chemical structure, and they combine the finest mechanical and thermal properties of polyamides with the most fabulous biodegradable properties of polyesters. PEAs can be manufactured via various monomers and adopting different synthesis procedures, leading to PEAs with ordered, blocky, and random structures. Mainly, PEAs comprising α-amino acids (α-AAs) have grown as essential biomaterials in the biomedical fields (e.g., drug delivery, tissue engineering, hydrogels, and smart materials). The existence of α -AAs offers to more reliable cell-polymer interactions, permits the establishment of carboxyl, hydroxyl, and amine pendant reaction groups, and improves the overall PEAs biodegradability. In this paper, a comprehensive review is bestowed on the current progress in the growth of α-AAs based PEAs and functionalized PEAs, the major polymerized routes utilized in their production along with their vital biomedical applications.

近年来，聚（酯酰胺）（PEA）已成为一类重要的合成生物可降解材料，并在各个领域得到了特殊应用。这些PEA在其化学结构中同时提供酰胺基和酯基，并且将聚酰胺的最佳机械性能和热性能与聚酯最出色的生物降解性能结合在一起。可以通过各种单体并采用不同的合成程序来制造PEA，从而导致PEA具有有序，块状和无规结构。在生物医学领域（例如，药物输送，组织工程，水凝胶和智能材料），包含α-氨基酸（α-AAs）的PEA主要已经作为必需的生物材料而生长。α-AAs的存在提供了更可靠的细胞-聚合物相互作用，允许建立羧基，羟基，和胺侧基反应基团，并改善了整体PEA的生物降解性。在本文中，对基于α-AAs的PEA和功能化PEA的增长，在其生产中使用的主要聚合途径及其重要的生物医学应用的当前进展进行了全面的综述。