This study investigated the impact of white matter hyperintensities (WMHs) on the progression from mild parkinsonian signs (MPS) to parkinsonism and Parkinson's disease (PD). Participants with MPS completed 5 years of follow-up. WMHs were divided into periventricular WMHs and deep WMHs according to magnetic resonance imaging scans. The diagnosis of MPS, parkinsonism, and PD was based on the motor portion of the Unified Parkinson's Disease Rating Scale. Cox proportional hazard models were used to identify the association between WMHs and MPS progression. Of the 636 participants, 166 (26.1%) with MPS developed parkinsonism and PD after follow-up. After adjusting for potential factors, severe WMHs were associated with an increased risk of MPS progression, moderate and severe periventricular WMHs and severe deep WMHs were associated with the risk of MPS progression, and severe WMHs were associated with the progression of gait/balance impairment, bradykinesia, and rigidity. Additionally, participants treated for vascular risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia had a lower risk of MPS progression.

中文翻译：

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白质高信号和从轻度帕金森症状到帕金森综合征和帕金森病的进展

本研究调查了白质高信号 (WMH) 对从轻度帕金森症状 (MPS) 到帕金森症和帕金森病 (PD) 进展的影响。MPS 参与者完成了 5 年的随访。WMHs根据磁共振成像扫描分为脑室周围WMHs和深部WMHs。MPS、帕金森综合征和 PD 的诊断基于统一帕金森病评定量表的运动部分。Cox 比例风险模型用于确定 WMH 与 MPS 进展之间的关联。在 636 名参与者中，166 名 (26.1%) 患有 MPS 的患者在随访后发展为帕金森综合征和 PD。在调整潜在因素后，严重的 WMH 与 MPS 进展的风险增加有关，中重度脑室周围 WMH 和重度深部 WMH 与 MPS 进展的风险相关，而重度 WMH 与步态/平衡障碍、运动迟缓和僵硬的进展相关。此外，接受高血压、糖尿病和高胆固醇血症等血管危险因素治疗的参与者发生 MPS 进展的风险较低。