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Antimicrobial susceptibility of Staphylococcus species isolated from prosthetic joints with a focus on fluoroquinolone-resistance mechanisms
Diagnostic Microbiology and Infectious Disease ( IF 2.1 ) Pub Date : 2020-08-12 , DOI: 10.1016/j.diagmicrobio.2020.115173 Kalifa Sanneh Darboe 1 , Tae-Hoon Oh 2 , Su-Mi Choi 2 , Hee-Kyung Kim 1 , Seong Eun Kim 2 , Uh Jin Kim 3 , Seung-Ji Kang 3 , Hee-Chang Jang 3 , Sook-In Jung 3 , Kyung-Hwa Park 3
中文翻译：
从假关节分离的葡萄球菌菌种的耐药性，重点是对氟喹诺酮类药物的耐药机制
更新日期：2020-09-28
Diagnostic Microbiology and Infectious Disease ( IF 2.1 ) Pub Date : 2020-08-12 , DOI: 10.1016/j.diagmicrobio.2020.115173 Kalifa Sanneh Darboe 1 , Tae-Hoon Oh 2 , Su-Mi Choi 2 , Hee-Kyung Kim 1 , Seong Eun Kim 2 , Uh Jin Kim 3 , Seung-Ji Kang 3 , Hee-Chang Jang 3 , Sook-In Jung 3 , Kyung-Hwa Park 3
Affiliation
We investigated susceptibility to antimicrobials of 89 staphylococcal species from PJIs and analyzed fluoroquinolone (FQ)-resistance mechanisms. Staphylococcal isolates showed high resistance to oral antimicrobials, with the exception of TMP-STX and linezolid. The main mechanism of resistance to FQ was mutations in quinolone-resistance-determining-regions. Fifteen percent of Staphylococcus aureus overexpressed efflux-pump genes.
中文翻译：
从假关节分离的葡萄球菌菌种的耐药性，重点是对氟喹诺酮类药物的耐药机制
我们调查了来自PJI的89种葡萄球菌对抗生素的敏感性，并分析了对氟喹诺酮（FQ）的耐药机制。除TMP-STX和利奈唑胺外，葡萄球菌分离株对口服抗菌药均显示高耐药性。对FQ产生抗性的主要机制是喹诺酮抗性决定区域中的突变。15％的金黄色葡萄球菌过表达外排泵基因。
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