Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is a severe global pandemic, affecting mostly the respiratory system. Understandably, attention is also being directed towards the urogenital tract. In this work, expression patterns of various host molecules possibly involved in viral entry and replication were investigated in human female and male reproductive systems by inquiring online repositories, including the Human Protein Atlas, GTEx, FANTOM5. Our findings highlight that male reproductive tissues could be targeted by SARS-CoV-2, particularly the testis since it co-expresses the receptor (ACE2) and the protease (TMPRSS) needed for viral entry. We hypothesized that SARS-CoV-2 infection could have repercussions on the fertility status of male individuals Potential infectivity of SARS-CoV-2 in reproductive tissues should be considered in reproductive medicine and management of in vitro fertilization in present and future generations.

由严重急性呼吸系统综合症引起的冠状病毒病2019（COVID-19）–冠状病毒2（SARS-CoV-2）是严重的全球大流行病，主要影响呼吸系统。可以理解，注意力也集中在泌尿生殖道上。在这项工作中，通过查询在线存储库，包括人类蛋白质图谱，GTEx，FANTOM5，研究了在人类女性和男性生殖系统中可能参与病毒进入和复制的各种宿主分子的表达模式。我们的发现突出表明，SARS-CoV-2（尤其是睾丸）可能靶向雄性生殖组织，因为它共表达病毒进入所需的受体（ACE2）和蛋白酶（TMPRSS）。