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Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial.
Drug Design, Development and Therapy ( IF 4.7 ) Pub Date : 2020-08-11 , DOI: 10.2147/dddt.s254150 Dongyue Wang 1 , Min Wang 1 , Hui Zhang 1 , He Zhu 1 , Na Zhang 1 , Jindong Liu 2
Drug Design, Development and Therapy ( IF 4.7 ) Pub Date : 2020-08-11 , DOI: 10.2147/dddt.s254150 Dongyue Wang 1 , Min Wang 1 , Hui Zhang 1 , He Zhu 1 , Na Zhang 1 , Jindong Liu 2
Affiliation
Purpose: In this study, the effect of intravenous vitamin C during surgery on the incidence of postoperative pulmonary complications (PPCs) in patients undergoing cardiopulmonary bypass and cardiac surgery was observed, and its protective effect on the lungs was evaluated to provide a reference for clinical medication.
Patients and Methods: Patients undergoing cardiac surgery under cardiopulmonary bypass (CPB) were selected. The patients were divided into group A and group C by random sequence. Patients in group A received intravenous vitamin C 1 g 10 minutes after induction of anesthesia, 10 minutes before cardiac reanimation and at the moment of sternal closure. Patients in group C were intravenously injected with the same volume of saline at the same time. The primary outcome was the postoperative pulmonary complication severity score. Other outcomes were the incidence of PPCs, awakening time, extubation time, length of ICU stay, length of hospital stay, adverse events, oxygenation index (PaO2/FiO2), alveolar arterial oxygen partial pressure difference (A-aDO2), dynamic lung compliance (Cd) and static lung compliance (Cs).
Results: Seventy patients completed the study. Compared to group C, the postoperative pulmonary complication score [2(2– 3) vs 2(1– 2); P=0.009] and the incidence of postoperative pulmonary complications (32.43% vs 12.12%; P =0.043) were lower in group A. There were no significant differences in awakening time, extubation time, length of ICU stay, length of hospital stay, adverse events, PaO2/FiO2, A-aDO2, Cs, and Cd between the two groups (P> 0.05).
Conclusion: In summary, this small randomized trial including low-risk cardiac surgery patients shows that intravenous vitamin C may safely be administered and may be helpful to prevent PPCs after cardiac surgery.
Keywords: cardiac surgery, cardiopulmonary bypass, postoperative pulmonary complications, vitamin C
中文翻译：
静脉注射维生素 C 对心脏手术患者术后肺部并发症的影响：一项双盲、随机试验。
目的：本研究观察术中静脉注射维生素C对体外循环和心脏手术患者术后肺部并发症（PPCs）发生率的影响，评价其对肺部的保护作用，为临床提供参考。药物。
患者和方法：选择在体外循环（CPB）下接受心脏手术的患者。患者按随机顺序分为A组和C组。A组患者在麻醉诱导后10分钟、心脏复苏前10分钟和胸骨闭合时静脉注射维生素C 1 g。C组患者同时静脉注射等量生理盐水。主要结果是术后肺部并发症严重程度评分。其他结果是 PPC 的发生率、觉醒时间、拔管时间、ICU 住院时间、住院时间、不良事件、氧合指数 (PaO 2 /FiO 2 )、肺泡动脉氧分压差 (A-aDO 2)、动态肺顺应性 (Cd) 和静态肺顺应性 (Cs)。
结果： 70 名患者完成了研究。与C组相比，术后肺部并发症评分[2(2-3) vs 2(1-2)；P = 0.009]，A组术后肺部并发症发生率（32.43% vs 12.12%；P = 0.043）较低。苏醒时间、拔管时间、ICU住院时间、住院时间、不良事件、PaO 2 / FiO 2、A-aDO 2、Cs、Cd两组比较（P > 0.05）。
结论：总之，这项包括低风险心脏手术患者的小型随机试验表明，静脉注射维生素 C 可能是安全的，并且可能有助于预防心脏手术后的 PPC。
关键词：心脏手术，体外循环，术后肺部并发症，维生素C
更新日期：2020-08-11
Patients and Methods: Patients undergoing cardiac surgery under cardiopulmonary bypass (CPB) were selected. The patients were divided into group A and group C by random sequence. Patients in group A received intravenous vitamin C 1 g 10 minutes after induction of anesthesia, 10 minutes before cardiac reanimation and at the moment of sternal closure. Patients in group C were intravenously injected with the same volume of saline at the same time. The primary outcome was the postoperative pulmonary complication severity score. Other outcomes were the incidence of PPCs, awakening time, extubation time, length of ICU stay, length of hospital stay, adverse events, oxygenation index (PaO2/FiO2), alveolar arterial oxygen partial pressure difference (A-aDO2), dynamic lung compliance (Cd) and static lung compliance (Cs).
Results: Seventy patients completed the study. Compared to group C, the postoperative pulmonary complication score [2(2– 3) vs 2(1– 2); P=0.009] and the incidence of postoperative pulmonary complications (32.43% vs 12.12%; P =0.043) were lower in group A. There were no significant differences in awakening time, extubation time, length of ICU stay, length of hospital stay, adverse events, PaO2/FiO2, A-aDO2, Cs, and Cd between the two groups (P> 0.05).
Conclusion: In summary, this small randomized trial including low-risk cardiac surgery patients shows that intravenous vitamin C may safely be administered and may be helpful to prevent PPCs after cardiac surgery.
Keywords: cardiac surgery, cardiopulmonary bypass, postoperative pulmonary complications, vitamin C
中文翻译：
静脉注射维生素 C 对心脏手术患者术后肺部并发症的影响：一项双盲、随机试验。
目的：本研究观察术中静脉注射维生素C对体外循环和心脏手术患者术后肺部并发症（PPCs）发生率的影响，评价其对肺部的保护作用，为临床提供参考。药物。
患者和方法：选择在体外循环（CPB）下接受心脏手术的患者。患者按随机顺序分为A组和C组。A组患者在麻醉诱导后10分钟、心脏复苏前10分钟和胸骨闭合时静脉注射维生素C 1 g。C组患者同时静脉注射等量生理盐水。主要结果是术后肺部并发症严重程度评分。其他结果是 PPC 的发生率、觉醒时间、拔管时间、ICU 住院时间、住院时间、不良事件、氧合指数 (PaO 2 /FiO 2 )、肺泡动脉氧分压差 (A-aDO 2)、动态肺顺应性 (Cd) 和静态肺顺应性 (Cs)。
结果： 70 名患者完成了研究。与C组相比，术后肺部并发症评分[2(2-3) vs 2(1-2)；P = 0.009]，A组术后肺部并发症发生率（32.43% vs 12.12%；P = 0.043）较低。苏醒时间、拔管时间、ICU住院时间、住院时间、不良事件、PaO 2 / FiO 2、A-aDO 2、Cs、Cd两组比较（P > 0.05）。
结论：总之，这项包括低风险心脏手术患者的小型随机试验表明，静脉注射维生素 C 可能是安全的，并且可能有助于预防心脏手术后的 PPC。
关键词：心脏手术，体外循环，术后肺部并发症，维生素C
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