Atomic engineering of single-atom nanozymes for enzyme-like catalysis,Chemical Science

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Atomic engineering of single-atom nanozymes for enzyme-like catalysis
Chemical Science ( IF 7.6 ) Pub Date : 2020-08-11 , DOI: 10.1039/d0sc03522j
Weiwei Wu _{1,

2} , Liang Huang _{1,

2} , Erkang Wang _{1,

2} , Shaojun Dong _{1,

2}

Affiliation

Enzyme mimics, especially nanozymes, play a crucial role in replacing natural enzymes for diverse applications related to bioanalysis, therapeutics and other enzyme-like catalysis. Nanozymes are catalytic nanomaterials with enzyme-like properties, which currently face formidable challenges with respect to their intricate structure, properties and mechanism in comparison with enzymes. The latest emergence of single-atom nanozymes (SAzymes) undoubtedly promoted the nanozyme technologies to the atomic level and provided new opportunities to break through their inherent limitations. In this perspective, we discuss key aspects of SAzymes, including the advantages of the single-site structure, and the derived synergetic enhancements of enzyme-like activity, catalytic selectivity and the mechanism, as well as the superiority in biological and catalytic applications, and then highlight challenges that SAzymes face and provide relevant guidelines from our point of view for the rational design and extensive applications of SAzymes, so that SAzyme may achieve its full potential as the next-generation nanozyme.

中文翻译：

用于类酶催化的单原子纳米酶的原子工程

酶模拟物，尤其是纳米酶，在生物分析、治疗和其他类酶催化相关的多种应用中替代天然酶方面发挥着至关重要的作用。纳米酶是具有类酶性质的催化纳米材料，与酶相比，其复杂的结构、性质和机制目前面临着巨大的挑战。最新出现的单原子纳米酶（SAzymes）无疑将纳米酶技术提升到了原子水平，并为突破其固有局限性提供了新的机遇。从这个角度来看，我们讨论了SAzymes的关键方面，包括单位点结构的优势，以及衍生的类酶活性、催化选择性和机制的协同增强，以及在生物和催化应用中的优越性，以及然后重点介绍了SAzymes面临的挑战，并从我们的角度为SAzymes的合理设计和广泛应用提供了相关指导，使SAzymes能够充分发挥其作为下一代纳米酶的潜力。

更新日期：2020-09-23

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