3-Amino-1,2,4-triazines are considered versatile compounds for its significance as building blocks in synthetic and pharmaceutical chemistry. The synthesis, chemical reactivity, and applications of substituted 1,2,4-triazines bearing an amino group were described in this review. The presence of the amino group at position 3 exhibited unique reactivities towards carbonitrile, carbonyl and isothiocyanate reagents. The reactions were divided into several categories, depending on the other substituents on the 1,2,4-triazine ring. In this review, relevant and appropriate applications of the synthesized, isolated, and condensed heterocycles derivatives were reported.

3-氨基1,2,4-三嗪被认为是通用化合物，因为它在合成和药物化学中作为重要组成部分而具有重要意义。在这篇综述中描述了带有氨基的取代的1,2,4-三嗪的合成，化学反应性和应用。在3位的氨基的存在表现出对腈，羰基和异硫氰酸酯试剂的独特反应性。根据1,2,4-三嗪环上的其他取代基，反应分为几类。在这篇综述中，报道了合成，分离和稠合的杂环衍生物的相关和适当的应用。