A central question in neuroscience is how cognition and consciousness arise from human brain activity. Here, we decompose cortical dynamics of resting-state functional MRI into their constituent elements: the harmonics of the human connectome. Mapping a wide spectrum of consciousness onto these elementary brain states reveals a generalisable connectome harmonic signature of loss of consciousness, whether due to anaesthesia or severe brain injury. Remarkably, its mirror-reversed image corresponds to the harmonic signature of the psychedelic state induced by ketamine or LSD, identifying meaningful relationships between neurobiology, brain function, and conscious experience. The repertoire of connectome harmonics further provides a fine-tuned indicator of level of consciousness, sensitive to differences in anaesthetic dose and clinically relevant sub-categories of patients with disorders of consciousness. Overall, we reveal that the emergence of consciousness from human brain dynamics follows the same universal principles shared by a multitude of physical and biological phenomena: the mathematics of harmonic modes.

中文翻译：

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人脑动力学的Connectome谐波分解揭示了一种意识形态

神经科学中的一个中心问题是人类大脑活动如何产生认知和意识。在这里，我们将静止状态功能MRI的皮质动力学分解为它们的组成元素：人类连接体的谐波。将广泛的意识映射到这些基本的脑部状态，可以发现由于麻醉或严重的脑损伤而导致的失去意识的通用连接词组谐波特征。值得注意的是，其镜像反转图像对应于由氯胺酮或LSD引起的迷幻状态的谐波特征，从而确定了神经生物学，脑功能和意识体验之间的有意义的关系。连接组谐波的所有组成部分进一步提供了意识水平的微调指标，对意识障碍患者的麻醉剂量和临床相关亚类的差异敏感。总的来说，我们揭示了人类大脑动力学意识的出现遵循着许多物理和生物现象所共有的相同的普遍原理：谐波模式的数学。