The SARS coronavirus 2 main protease 3CLpro tailor cuts various essential virus proteins out of long poly-protein translated from the virus RNA. If the 3CLpro is inhibited, the functional virus proteins cannot form and the virus cannot replicate and assemble. Any compound that inhibits the 3CLpro is therefore a potential drug to end the pandemic. Here we show that the diffraction power of 3CLpro crystals is effectively destroyed by Ebselen. It appears that Ebselen may be a widely available, relatively cost effective way to eliminate the SARS coronavirus 2.

中文翻译：

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Ebselen与SARS冠状病毒2主要蛋白酶晶体发生反应

SARS冠状病毒2主要蛋白酶3CLpro剪裁从病毒RNA翻译出来的长多聚蛋白中切出各种必需的病毒蛋白。如果3CLpro被抑制，则功能性病毒蛋白将无法形成，并且病毒将无法复制和组装。因此，任何抑制3CLpro的化合物都是终止大流行的潜在药物。在这里，我们证明了3CLpro晶体的衍射能力被Ebselen有效破坏了。看来，Ebselen可能是消除SARS冠状病毒2的一种广泛使用且相对经济有效的方法。