The emergence of novel designer benzodiazepines continues to be a public health concern. Flualprazolam is one of these drugs. It was initially identified in 2017. User forums suggest it is slightly more potent than alprazolam and has longer-lasting central nervous system depressant effects. Here we report a simple, sensitive liquid chromatography–tandem mass spectrometry method for flualprazolam and report a series of nine cases in which flualprazolam was quantified. As is typical of forensic toxicology in the twenty-first century, all the cases had more than one drug present. None of the deaths could be directly attributed to flualprazolam alone, but all were likely due to a combination of sedative drugs. However, this paper still adds to the data available to allow interpretation of postmortem flualprazolam concentrations.

中文翻译：

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LC-MS-MS定量分析血液中氟拉普唑仑：九例死亡病例

新颖的设计师苯二氮卓类药物的出现仍然是公共卫生问题。Flualprazolam是这些药物之一。它最初于2017年被发现。用户论坛显示，它的功效比阿普唑仑稍强，并且具有更长的中枢神经系统抑制作用。在这里，我们报告了一种简单，灵敏的液相色谱-串联质谱法测定氟普唑仑的方法，并报告了一系列定量检出氟普唑仑的9例病例。像二十世纪法医毒理学中的典型特征一样，所有案件中都存在不止一种药物。没有一个死亡可以直接归因于氟吡唑仑，但所有死亡都可能是由于镇静药的联合使用。然而，本文仍然增加了可用于解释死后氟普拉唑仑浓度的数据。