Histone deacetylases are typically involved in transcriptional repression, but a report in Nature describes a mechanism by which HDAC3 can also activate macrophage transcription in response to lipopolysaccharide in a deacetylase-independent manner.

中文翻译：

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LPS响应的高点和低点。

组蛋白脱乙酰基酶通常参与转录抑制，但是《自然》杂志的一篇报道描述了一种机制，通过该机制，HDAC3还可以以脱乙酰基酶非依赖性的方式响应于脂多糖而激活巨噬细胞转录。